王輝,1965.04-,博士、 二級(jí)教授、博士生導(dǎo)師,新鄉(xiāng)醫(yī)學(xué)院副校長(zhǎng)。河南省高等學(xué)校醫(yī)學(xué)技術(shù)類本科教學(xué)指導(dǎo)委員會(huì)主任委員,河南省免疫與靶向藥物重點(diǎn)實(shí)驗(yàn)室主任。
1999年中國(guó)協(xié)和醫(yī)科大學(xué)獲內(nèi)科學(xué)博士學(xué)位,師從于著名內(nèi)分泌學(xué)家史軼蘩院士。2002年獲得德國(guó)DADD生命科學(xué)博士后獎(jiǎng)學(xué)金,2002.1-2003.5德國(guó)科隆大學(xué)遺傳所博士后;2003.6-2003.12德國(guó)杜塞爾多夫大學(xué)博士后進(jìn)行博士后研究,師從于Markus Muschen教授(目前任職于耶魯大學(xué))?;貒?guó)后被評(píng)為河南省留學(xué)歸國(guó)人員先進(jìn)個(gè)人、河南省學(xué)術(shù)技術(shù)帶頭人、河南省第二批教學(xué)名師。目前研究方向?yàn)楦腥久庖吆痛x免疫。先后主持國(guó)家自然基金項(xiàng)目7項(xiàng)(其中聯(lián)合基金重點(diǎn)項(xiàng)目1項(xiàng))。在Cellular & Molecular Immunology、Cancer Immunol Res.、J Immunol、J Am Soc Nephrol、Int J Obes等雜志上發(fā)表SCI論文65篇。2019年被新疆醫(yī)科大學(xué)聘為免疫學(xué)專業(yè)博士研究生導(dǎo)師。主編和參編教材10多部,主編科普讀物兩部。近年獲得省科技進(jìn)步三等獎(jiǎng)三項(xiàng)。
【受教育經(jīng)歷】
1996.09-1999.07 中國(guó)協(xié)和醫(yī)科大學(xué)北京協(xié)和醫(yī)院 在職博士(導(dǎo)師 史軼蘩院士)
1987.09-1990.09 西安醫(yī)科大學(xué) 微生物與免疫學(xué)專業(yè) 碩士(導(dǎo)師 鐵衣 教授)
1981.09-1984.07,豫北醫(yī)學(xué)??茖W(xué)校(新鄉(xiāng)醫(yī)學(xué)院) 臨床醫(yī)學(xué)
【研究工作經(jīng)歷】
2016.06-任新鄉(xiāng)醫(yī)學(xué)院副校長(zhǎng)
2013.11-2016.09任新鄉(xiāng)醫(yī)學(xué)院檢驗(yàn)學(xué)院院長(zhǎng)
2004.08-2013.10任新鄉(xiāng)醫(yī)學(xué)院醫(yī)學(xué)檢驗(yàn)系主任(其中2008.11-2013.10兼任科技處處長(zhǎng))
2004.01-新鄉(xiāng)醫(yī)學(xué)院 教授
2003.06-2003.12 德國(guó)杜塞爾多夫大學(xué)醫(yī)學(xué)院 博士后(Markus Muschen實(shí)驗(yàn)室)
2002.01-2003.05 德國(guó)科隆大學(xué)遺傳所 博士后(Markus Muschen實(shí)驗(yàn)室)
1999.08-2001.12 新鄉(xiāng)醫(yī)學(xué)院基礎(chǔ)部 副教授 副主任
1995.04-1999.07 北京協(xié)和醫(yī)院衛(wèi)生部?jī)?nèi)分泌重點(diǎn)實(shí)驗(yàn)室 客座研究員
1990.09-1995.03 新鄉(xiāng)醫(yī)學(xué)院微生物與免疫學(xué)教研室 講師
1984.08-1987.08 信陽(yáng)地直公療醫(yī)院 內(nèi)科醫(yī)師
【承擔(dān)及完成的國(guó)家自然基金項(xiàng)目】
1. U21A20366, S100A10在慢性腸炎及其引起抑郁障礙中的免疫調(diào)節(jié)機(jī)制.區(qū)域創(chuàng)新基金項(xiàng)目,2022-01-01至2025-12-31。 直接經(jīng)費(fèi)260萬(wàn)元。
2. 81871309, BCL-3通過(guò)對(duì)慢性炎癥的調(diào)節(jié)參與肥胖小鼠的脂肪組織重構(gòu).面上項(xiàng)目, 2019-01-01至2022-12-31。直接經(jīng)費(fèi)57萬(wàn)元。
3. U1804190, Th2細(xì)胞對(duì)高脂飲食誘導(dǎo)的肥胖小鼠脂肪肝形成及代謝異常的影響. 聯(lián)合基金項(xiàng)目, 2019-01-01至2021-12-31。直接經(jīng)費(fèi)48萬(wàn)元。
4. 81471559, Bcl3對(duì)HTLV-1病毒感染細(xì)胞內(nèi)NFκB通路和細(xì)胞自噬作用的分子機(jī)制.面上項(xiàng)目, 2015-01-01至2018-12-31。經(jīng)費(fèi):75萬(wàn)元。
5. 81273241,在HTLV-1感染的T細(xì)胞中HMGB1、Tax蛋白與細(xì)胞自噬關(guān)系的研究.面上項(xiàng)目, 2013-01-01至2016-12-31。經(jīng)費(fèi):80萬(wàn)元。
6. 30972755,在HTLV-1病毒感染的T細(xì)胞中Bcl3-NFκB-Tax蛋白關(guān)系的研究.面上項(xiàng)目, 2010-01-01至2012-12-31。經(jīng)費(fèi):23萬(wàn)元。
7. 30670910,成人T細(xì)胞白血病相關(guān)基因的研究.面上項(xiàng)目,2007-01-01至2007-12-31。經(jīng)費(fèi):8萬(wàn)元。
【近幾年代表性論著】
Liu S, Wang H, Li J, Gao J, Yu L, Wei X, Cui M, Zhao Y, Liang Y, Wang H. Loss of Bcl-3 regulates macrophage polarization by promoting macrophage glycolysis. Immunol Cell Biol. 2024 May 28. doi: 10.1111/imcb.12785.
Su R, Kang X, Niu Y, Zhao T, Wang H. PCBP1 interacts with the HTLV-1 Tax oncoprotein to potentiate NF-κB activation. Front Immunol. 2024 Apr 16:15:1375168.
Liu H, Sun J, Wang Z, Han R, Zhao Y, Lou Y, Wang H. S100a10 deficiency in neutrophils aggravates ulcerative colitis in mice. Int Immunopharmacol. 2024 Feb 15;128:111499.
Dong L, Gao J, Yu L, Liu S, Zhao Y, Zhang W, Liang Y, Wang H. Polarized Th2 cells attenuate high-fat-diet induced obesity through the suppression of lipogenesis. BMC Immunol. 2024 Jan 10;25(1):4.
Liu H, Zeng L, Pan M, Huang L, Li H, Liu M, Niu X, Zhang C, Wang H. Bcl-3 regulates T cell function through energy metabolism. BMC Immunol. 2023 Oct 4;24(1):35
Lou Y, Jiang S, Song M, Wang H, Han M, Tian X, Zhao Y, Gao J, Song Y, Ma S, Zhao P, Zheng Q, Niu Z, Zhang W, Chang T, Chen YH, Wang H. Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF-α-Mediated Inflammation. J Immunol. 2023 Sep 1;211(5):874-884.
Duan L, Zhao Y, Jia J, Chao T, Wang H, Liang Y, Lou Y, Zheng Q, Wang H. Myeloid-restricted CD68 deficiency attenuates atherosclerosis via inhibition of ROS-MAPK-apoptosis axis. Biochim Biophys Acta Mol Basis Dis. 2023 Jun;1869(5):166698.
Wang J, Qin X, Huang Y, Zhang G, Liu Y, Cui Y, Wang Y, Pei J, Ma S, Song Z, Zhu X, Wang H, Yang B. Sirt1 Negatively Regulates Cellular Antiviral Responses by Preventing the Cytoplasmic Translocation of Interferon-Inducible Protein 16 in Human Cells. J Virol. 2023 Feb 28;97(2):e0197522.
Wang J, Qin X, Huang Y, Zhang Q, Pei J, Wang Y, Goren I, Ma S, Song Z, Liu Y, Xing H, Wang H, Yang B. TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection. Autophagy. 2023 Jun;19(6):1844-1862.
Liu H, Sun J, Cheng X, Duan L, Guo S, Zhang Z, Wan J, Wang C, Zhi X, Yuan L, Wang H. Hydrogen sulfide inhibits human T-cell leukemia virus type-1 (HTLV-1) protein expression via regulation of ATG4B. J Med Virol. 2023 Jan;95(1):e28176
Hui Liu, Lin Zeng , Yang Yang , Zhen Huang , Chunlei Guo, Liwenhui Huang, Xinqing Niu, Chenguang Zhang, Hui Wang*. Bcl-3 regulates the function of Th17 cells through raptor mediated glycolysis metabolism. Front Immunol. 2022 Sep 9:13:929785
Zheng Q#, Duan L#*, Jiang Z, Gu T, Zhang B, Li J, Zhang Y, Zhang S, Liang Y,Wang H*.Two human monoclonal SARS-CoV-2 antibodies that maintain neutralizing potency against the SARS-CoV-2 Omicron BA.1 and BA.2 variants.Genes Dis.2022 Jun 7. doi: 10.1016/j.gendis.2022.05.027.
Lou Y#, Song M#, Han M, Zhong J, Tian X, Ren Y, Song Y, Duan L, Zhao P, Song X, Zhang W, Chen YH,Wang H*. Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer.Cancer Immunol Res. 2022; 10(3):354-367.
Hui Liu#,Lin Zeng,Yang Yang,Chunlei Guo,Hui Wang*. Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation.Front. Immunol. 2022 ;13:847699.
Lou Y#, Tian X#, Sun C#, Song M, Han M, Zhao Y, Song Y, Song X, Zhang W, Chen YH,Wang H*. TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis.Cell Death Dis. 2022; 13(4):311.
Zheng Q#, Duan L, Lou Y, Chao T, Guo G, Lu L, Zhang H, Zhao Y, Liang Y,Wang H*. Slfn4 deficiency improves MAPK-mediated inflammation, oxidative stress, apoptosis and abates atherosclerosis progression in apolipoprotein E-deficient mice.Atherosclerosis. 2021 ;337:42-52.
Zhang S#, Gao J, Liu S, Yu L, Zhang W, Liang Y, Wang H*. Transcription Coactivator BCL3 Acts as a Potential Regulator of Lipid Metabolism Through the Effects on Inflammation.J Inflamm Res. 2021 ;14:4915-4926.
Guo C#, Li S, Liang A, Cui M, Lou Y,Wang H*. PPA1 Promotes Breast Cancer Proliferation and Metastasis Through PI3K/AKT/GSK3βSignaling Pathway.Front Cell Dev Biol.2021 ;9:730558.
Zhang WJ#, Chen SJ, Zhou SC, Wu SZ*,Wang H*. Inflammasomes and Fibrosis.Front Immunol.2021 ;12:643149.
Lou Y#, Han M#, Liu H, Niu Y, Liang Y, Guo J, Zhang W, Wang H*. Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection.Cell Mol Immunol.2020; 17(10):1053-1062.
Duan L#, Zheng Q, Zhang H, Niu Y, Lou Y,Wang H*. The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens.Front Immunol.2020 ;11:576622.
Lou Y#, Han M#, Song Y, Zhong J, Zhang W, Chen Y,Wang H*. The SCFβ-TrCP E3 ubiquitin ligase regulates immune receptor signaling by targeting the negative regulatory protein TIPE2.J Immunol.2020; 204(8):2122-2132.
Yang B#, Liu Y, Cui Y, Song D, Zhang G, Ma S, Liu Y, Chen M, Chen F,Wang H*, Wang J*. RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation.PLoS Pathog. 2020 ;16(3):e1008387.
Niu Y#, Yang X, Chen Y, Jin X, Li L, Guo Y, Li X, Xie Y, Zhang Y,Wang H*. EVI1 induces autophagy to promote drug resistance via regulation of ATG7 expression in leukemia cells.Carcinogenesis.2020 ;41(7):961-971.
Cao Q#*, Wang Y, Niu Z, Wang C, Wang R, Zhang Z, Chen T, Wang XM, Li Q, Lee VWS, Huang Q, Tan J, Guo M, Wang YM, Zheng G, Yu D, Alexander SI,Wang H*, Harris DCH. Potentiating Tissue-Resident Type 2 Innate Lymphoid Cells by IL-33 to Prevent Renal Ischemia-Reperfusion Injury.J Am Soc Nephrol. 2018 ;29(3):961-976.
【獲得的科研獎(jiǎng)勵(lì)和榮譽(yù)】
(1)溴隱亭、催乳素與T淋巴細(xì)胞關(guān)系的研究 河南省科技進(jìn)步三等獎(jiǎng)(第二)2011
(2)成人T細(xì)胞白血病相關(guān)基因研究與應(yīng)用 河南省科技進(jìn)步三等獎(jiǎng)(第一)2014
(3) 細(xì)胞自噬和DNA識(shí)別受體與HTLV-1病毒復(fù)制的關(guān)系 河南省科技進(jìn)步三等獎(jiǎng)(第一)2019
【學(xué)術(shù)任職】
中國(guó)免疫學(xué)會(huì)第六屆、第八屆常務(wù)理事
中國(guó)免疫學(xué)會(huì)科普與教育工作委員會(huì) 副主任委員
河南省免疫學(xué)會(huì)第二屆理事會(huì)理事長(zhǎng)
河南省生物物理學(xué)會(huì)第一屆理事會(huì)副理事長(zhǎng)
《Immune Discovery》主編
《中國(guó)免疫學(xué)雜志》(2014-2018)編委
《細(xì)胞與分子免疫學(xué)雜志》(2013--)編委
《國(guó)際免疫學(xué)雜志》(2013--)編委
《新鄉(xiāng)醫(yī)學(xué)院學(xué)報(bào)》主編
上一條:梁銀明
【關(guān)閉】
地址:河南省新鄉(xiāng)市紅旗區(qū)金穗大道601號(hào)
版權(quán)所有:河南省免疫與靶向藥物重點(diǎn)實(shí)驗(yàn)室