梁銀明，41歲，中共黨員。實(shí)驗(yàn)室立足于小鼠模型探索疾病機(jī)制、開發(fā)了粒細(xì)胞缺陷等系列特色動(dòng)物模型。取得了以下學(xué)術(shù)成績(jī)：第一、首次發(fā)現(xiàn)RLTPR作為免疫應(yīng)答關(guān)鍵調(diào)控“開關(guān)”，解開了T淋巴細(xì)胞共刺激信號(hào)傳導(dǎo)之謎，相關(guān)結(jié)果在Nature Immunology發(fā)表（DOI 10.1038/ni.2634），該分子于2016年被《科學(xué)-細(xì)胞信號(hào)》評(píng)為細(xì)胞信號(hào)研究重大突破。第二、首次實(shí)現(xiàn)在小鼠活體水平對(duì)成熟T細(xì)胞內(nèi)靶基因進(jìn)行條件性剔除。該模型部分結(jié)果在Nature Immunology發(fā)表（DOI 10.1038/ni.2843）。第三、構(gòu)建我國(guó)第一個(gè)免疫模式動(dòng)物平臺(tái)。平臺(tái)擁有免疫研究相關(guān)動(dòng)物模型品系超過300個(gè)，保存活體小鼠品系超過100個(gè)。第四、構(gòu)建了小鼠及細(xì)胞系快速基因編輯方案，相關(guān)研究以共同通訊作者2019年10月在Nature Immunology發(fā)表，并獲國(guó)內(nèi)外媒體報(bào)道。近期研究結(jié)果以通訊作者在PLoS Pathogens、EMBO Reports、SCIENCE CHINA Life Sciences等國(guó)際著名期刊發(fā)表。在動(dòng)物模型構(gòu)建技術(shù)及基礎(chǔ)研究方面取得了系列進(jìn)步。研發(fā)了新一代人源化小鼠，在國(guó)外動(dòng)物模型的基礎(chǔ)上，實(shí)現(xiàn)了粒細(xì)胞缺失，進(jìn)一步優(yōu)化了人源化受體小鼠方案。實(shí)驗(yàn)室聚焦免疫相關(guān)重大疾病動(dòng)物模型研究及致病機(jī)制研究，是我國(guó)該領(lǐng)域最為活躍的實(shí)驗(yàn)室之一。
【受教育經(jīng)歷】
2009年9月–2013年10月，Aix-Marseille大學(xué)，免疫學(xué)博士
2006年9月–2009年6月，東華大學(xué)，生物化學(xué)與分子生物學(xué)碩士
1999年9月–2004年6月，湖南中醫(yī)藥大學(xué)，中醫(yī)學(xué)，學(xué)士
【研究工作經(jīng)歷】
2013.11-至今 新鄉(xiāng)醫(yī)學(xué)院醫(yī)學(xué)檢驗(yàn)學(xué)院 講師、特聘教授
【承擔(dān)及完成國(guó)家級(jí)/省級(jí)課題】
1.河南省杰出青年科學(xué)基金項(xiàng)目，222300420015，慢性炎癥機(jī)制及動(dòng)物模型研究，2022年1月至2024年12月，在研，主持
2.國(guó)家自然科學(xué)基金面上項(xiàng)目，32070898，LAT介導(dǎo)的負(fù)反饋障礙導(dǎo)致T細(xì)胞增殖失控的機(jī)制，2021年1月至2024年12月，在研，主持
【代表性論著】（#為第一作者，*為通訊作者）
1. Liaoxun Lu*, Tianhan Li, Xinyu Feng, Zhilong Liu, Yang Liu, Tianzhu Chao, Yanrong Gu, Rong Huang, Fanghui Zhang, Le He, Binhui Zhou, Eryan Kong, Zhuangzhuang Liu1, Xugang Wang, Zhijun Chen, Hui Wang, Marie Malissen, Bernard Malissen, Lichen Zhang*,Yinming Liang*. Excessive immunosuppression by regulatory T cells antagonizes T cell response to schistosome infection in PD-1-deficient mice .PLOS PATHOGENS. 2022;18(6): e1010596.
2. Wenyi Yang, Binhui Zhou,QiLiu, Taozhen Liu, Huijie Wang, Pei Zhang, Liaoxun Lu, Lichen Zhang, Fanghui Zhang, Rong Huang , Jitong Zhou, Tianzhu Chao,Yanrong Gu, Songhua Lee, Hui Wang *,Yinming Liang*and Le He*. A Murine Point Mutation ofSgpl1Skin Is Enriched With Vg6IL17-Producing Cell and Revealed With Hyperpigmentation After Imiquimod Treatment. Frontiers in Immunology.Frontiers in Immunology.2022；2022.728455
3. He L, Valignat MP, Zhang L, Gelard L, Zhang F, Le Guen V, Audebert S, Camoin L, Fossum E, Bogen B, Wang H, Henri S, Roncagalli R, Theodoly O,Liang Y*, Malissen M*, Malissen B*. ARHGAP45 controls naive T- and B-cell entry into lymph nodes and T-cell progenitor thymus seeding.EMBO Rep. 2021;22:e52196.
4. Wang Y, Fu Z, Li X,Liang Y, Pei S, Hao S, Zhu Q, Yu T, Pei Y, Yuan J, Ye J, Fu J, Xu J, Hong J, Yang R, Hou H, Huang X, Peng C, Zheng M, Xiao Y. Cytoplasmic DNA sensing by KU complex in aged CD4(+) T cell potentiates T cell activation and aging-related autoimmune inflammation.Immunity. 2021;54:632-647 e639.
5. Chao T, Lu L, Zhang L, Huang R, Liu Z, Zhou B, Kong E, Zhang Z, Lawrence T*,Liang Y*. An inducible model for specific neutrophil depletion by diphtheria toxin in mice.Sci China Life Sci.2021;64:1227-1235.
6. Zhang L, Huang R, Lu L, Fu R, Guo G, Gu Y, Liu Z, He L, Malissen M,Liang Y*. Gene Knock-in by CRISPR/Cas9 and Cell Sorting in Macrophage and T Cell Lines.J Vis Exp. 2021.
7. Zheng Q, Duan L, Lou Y, Chao T, Guo G, Lu L, Zhang H, Zhao Y,Liang Y*, Wang H*. Slfn4 deficiency improves MAPK-mediated inflammation, oxidative stress, apoptosis and abates atherosclerosis progression in apolipoprotein E-deficient mice.Atherosclerosis. 2021;337:42-52.
8. Zhou B, Lawrence T,Liang Y*. The Role of Plasmacytoid Dendritic Cells in Cancers.Front Immunol. 2021;12:749190.
9. Lu L, Hu J, Chao T, Chen Z, Liu Z, Luo X,Liang Y, He P, Zhang L. Loss of natural resistance to schistosome in T cell deficient rat.PLoS Negl Trop Dis. 2020;14:e0008909.
10. Voisinne G, Kersse K, Chaoui K, Lu L, Chaix J, Zhang L, Goncalves Menoita M, Girard L, Ounoughene Y, Wang H, Burlet-Schiltz O, Luche H, Fiore F, Malissen M, Gonzalez de Peredo A,Liang Y*, Roncagalli R*, Malissen B*. Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.Nat Immunol. 2019;20:1530-1541.
11. Huang R, Guo G, Lu L, Fu R, Luo J, Liu Z, Gu Y, Yang W, Zheng Q, Chao T, He L, Wang Y, Niu Z, Wang H, Lawrence T, Malissen M, Malissen B,Liang Y*,
Zhang L*. The three members of the Vav family proteins form complexes that concur to foam cell formation and atherosclerosis.J Lipid Res. 2019;60:2006-2019.
12. Chao T, Liu Z, Zhang Y, Zhang L, Huang R, He L, Gu Y, Chen Z, Zheng Q, Shi L, Zheng W, Qi X, Kong E, Zhang Z, Lawrence T,Liang Y*, Lu L*. Precise and Rapid Validation of Candidate Gene by Allele Specific Knockout With CRISPR/Cas9 in Wild Mice.Front Genet. 2019;10:124.
13. Luo J, Lu L, Gu Y, Huang R, Gui L, Li S, Qi X, Zheng W, Chao T, Zheng Q,Liang Y*, Zhang L*. Speed genome editing by transient CRISPR/Cas9 targeting and large DNA fragment deletion.J Biotechnol. 2018;281:11-20.
14. Wang X, Huang R, Zhang L, Li S, Luo J, Gu Y, Chen Z, Zheng Q, Chao T, Zheng W, Qi X, Wang L, Wen Y,Liang Y*, Lu L*. A severe atherosclerosis mouse model on the resistant NOD background.Dis Model Mech. 2018;11.
15. Zhang X, Wang Y, Yuan J, Li N, Pei S, Xu J, Luo X, Mao C, Liu J, Yu T, Gan S, Zheng Q,Liang Y, Guo W, Qiu J, Constantin G, Jin J, Qin J, Xiao Y. Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3.J Exp Med. 2018;215:1365-1382.
16. Roncagalli R, Cucchetti M, Jarmuzynski N, Gregoire C, Bergot E, Audebert S, Baudelet E, Menoita MG, Joachim A, Durand S, Suchanek M, Fiore F, Zhang L, LiangY, Camoin L, Malissen M, Malissen B. The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells.J Exp Med. 2016;213:2437-2457.
17. Roncagalli R, Hauri S, Fiore F,Liang Y, Chen Z, Sansoni A, Kanduri K, Joly R, Malzac A, Lahdesmaki H, Lahesmaa R, Yamasaki S, Saito T, Malissen M, Aebersold R, Gstaiger M, Malissen B. Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.Nat Immunol. 2014;15:384-392.
18. Liang Y, Cucchetti M, Roncagalli R, Yokosuka T, Malzac A, Bertosio E, Imbert J, Nijman IJ, Suchanek M, Saito T, Wulfing C, Malissen B, Malissen M. The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.Nat Immunol. 2013;14:858-866.
19. Ordonez-Rueda D, Jonsson F, Mancardi DA, Zhao W, Malzac A,Liang Y, Bertosio E, Grenot P, Blanquet V, Sabrautzki S, de Angelis MH, Meresse S, Duprez E, Bruhns P, Malissen B, Malissen M. A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia.Eur J Immunol. 2012;42:2395-2408.
【獲得的科研獎(jiǎng)勵(lì)和榮譽(yù)】
1. 2021年度河南高等教育突出貢獻(xiàn)人物，河南日?qǐng)?bào)社黃河教育獎(jiǎng)組委會(huì)，2021年
2. 河南省高等學(xué)校優(yōu)秀共產(chǎn)黨員，中共河南省委高等學(xué)校工作委員會(huì)，2020年
3. 河南省優(yōu)秀碩士學(xué)位論文指導(dǎo)教師，河南省教育廳，省級(jí)，2018年
4. 五一勞動(dòng)獎(jiǎng)?wù)拢锣l(xiāng)市總工會(huì)，2017年
5. 中國(guó)免疫學(xué)會(huì)青年學(xué)者獎(jiǎng)，中國(guó)免疫學(xué)會(huì)，2014年
【學(xué)術(shù)任職】
河南省實(shí)驗(yàn)動(dòng)物學(xué)會(huì)副理事長(zhǎng)
Frontiers in Immunology審稿編輯、Nature Immunology論文評(píng)審
