鄭前前（1986.06-），理學博士，講師，碩士生導師。主持國家自然科學基金兩項，2017年入選新鄉(xiāng)醫(yī)學院“太行青年學者”。從事疾病相關蛋白的結構與功能研究,目前主要聚焦于動脈粥樣硬化的發(fā)病機制研究、新發(fā)再發(fā)傳染病病原入侵細胞的分子機制及其人源中和抗體研究。
【受教育經(jīng)歷】
2013.09-2016.06 南開大學 生物化學與分子生物學專業(yè) 博士
2010.09-2013.06 南開大學 生物化學與分子生物學專業(yè) 碩士
2006.09-2010.07 河南科技學院 生物工程專業(yè) 本科
【研究工作經(jīng)歷】
2016.07-至今 新鄉(xiāng)醫(yī)學院醫(yī)學檢驗學院 講師
【承擔及完成國家級/省級課題】
1. CD68通過Vav1調(diào)控CD36介導泡沫細胞形成的機制（81871312），國家自然科學基金面上項目，2019.01-2022.12，57萬元；
2. Gfi1雙重調(diào)節(jié)高脂血癥小鼠單核巨噬細胞分化與泡沫細胞形成的機制（81701546），國家自然科學基金青年項目，2018.01-2020.12，20萬元。
【代表性論著】（#為第一作者，*為通訊作者）
1.Zheng Q#, Duan L#, Jiang Z, Gu T, Zhang B, Li J, Zhang Y, Zhang S, Liang Y, Wang H*. Two human monoclonal SARS-CoV-2 antibodies that maintain neutralizing potency against the SARS-CoV-2 Omicron BA.1 and BA.2 variants. Genes Dis, 2022; doi: 10.1016/j.gendis.2022.05.027.
2.Zheng Q#, Duan L#, Zhang Y, Li J, Zhang S, Wang H*. A dynamically evolving war between autophagy and pathogenic microorganisms.J Zhejiang Univ Sci B. 2022; 23(1):19-41.
3.Zheng Q#,Duan L#, Lou Y, Chao T, Guo G, Lu L, Zhang H, Zhao Y, Liang Y, Wang H*. Slfn4 deficiency improves MAPK-mediated inflammation, oxidative stress, apoptosis and abates atherosclerosis progression in apolipoprotein E-deficient mice. Atherosclerosis. 2021; 337:42-52.
4. Duan L#,Zheng Q,Zhang H, Niu Y, Lou Y, Wang H*. The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens. Front Immunol. 2020; 11:576622.
5. Guo G#, Fu R, Zhang L, Chao T, Jiang Z, Dong L, Huang R, Lu L, Yang W, Gu Y, Liang Y,Zheng Q*. Gfi1 and Zc3h12c orchestrate a negative feedback loop that inhibits NF-kB activation during inflammation in macrophages.Mol Immunol. 2020; 128:219-226.
6. Zhang X#, Wang Y, Yuan J, Li N, Pei S, Xu J, Luo X, Mao C, Liu J, Yu T, Gan S,Zheng Q,Liang Y, Guo W, Qiu J, Constantin G, Jin J, Qin J, Xiao Y*. Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3. J Exp Med. 2018; 215(5):1365-1382.
7.Wang H#, Li S, Chao T, Wang X, Shi L, Zhang L, Liang Y,Zheng Q*, Lu L*. A point mutation in the extracellular domain of CD4 completely abolishes CD4 T cell development in C57BL/6 mouse. Mol Immunol. 2017; 92:12-20.
8.Zheng Q#, Song Y#, Zhang W, Shaw N, Zhou W*, Rao Z*. Structural views of quinone oxidoreductase from Mycobacterium tuberculosis reveal large conformational changes induced by the co-factor. FEBS J. 2015; 282(14):2697-707.
9. Jiang D#, Zhang Q,Zheng Q, Zhou H, Jin J, Zhou W, Bartlam M*, Rao Z*. Structural analysis of Mycobacterium tuberculosis ATP-binding cassette transporter subunit UgpB reveals specificity for glycerophosphocholine. FEBS J. 2014; 281(1):331-41.
10.Zheng Q#, Jiang D#, Zhang W, Zhang Q, Zhao Q, Jin J, Li X, Yang H, Bartlam M, Shaw N, Zhou W*, Rao Z*. Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase. J Biol Chem. 2014; 289(31):21242-51.
【知識產(chǎn)權（包括專利）】
1.段良偉;王輝;鄭前前;牛玉娜;牛志國;張佳璐;劉夢楠;一種重組EBV gHgL免疫原的制備方法及其應用2022-6-20中國CN202010026943.7（授權專利）
【學術任職】
