劉慧，1991.12-，博士、講師、碩士生導師。2018年于南開大學取得博士學位，師從免疫學家尹芝南教授。目前研究方向為代謝免疫和腫瘤疫苗，主要從事T細胞代謝與免疫功能的研究、小分子藥物對腫瘤的靶向治療研究及腫瘤疫苗的制備及免疫相關(guān)研究。
郵箱：hsdliuhui@163.com
【受教育經(jīng)歷】
2013.09 ~ 2018.07 南開大學生命科學學院 生物化學與分子生物學 碩博連讀
2009.09 ~ 2013.07 河南師范大學生命科學學院 生物科學 理學學士
【工作經(jīng)歷】
2018.07 ~至今 新鄉(xiāng)醫(yī)學院醫(yī)學檢驗學院 臨床免疫學教研室 講師
【承擔及完成國家級/省級課題】
1. Bcl-3通過mTORC1信號通路調(diào)節(jié)CD4+T細胞代謝及功能的機制研究，劉慧，國家自然科學基金，2020.01-2022.12.31，No. 81901590，21萬元；
2. β葡聚糖包含鋁佐劑作為新的抗原負載系統(tǒng)在乙肝疫苗當中的免疫作用機制的研究，劉慧，河南省教育廳，2020.01-2021.12.31，No. 20A310014，3萬元；
【發(fā)表SCI論文】
[1] Hui Liu; Lin Zeng; Yang Yang; Chunlei Guo; Hui Wang; Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation, Frontiers in Immunology, 2022 ;13:847699.
[2] Hui Liu; Chunlei Guo; Yuhong Shang; Lin Zeng; Haixue Jia; Zhongyan Wang; A Supramolecular Nanoparticle of Pemetrexed Improves the Anti-Tumor Effect by Inhibiting Mitochondrial Energy Metabolism, Frontiers in Bioengineering and Biotechnology,2021 ;9:804747.
[3] Liu H, Meng Z, Wang H, Zhang S, Huang Z, Geng X, Guo R, Wu Z, Hong Z. Robust Immune Responses Elicited by a Hybrid Adjuvant Based on β-Glucan Particles from Yeast for the Hepatitis B Vaccine. ACS Appl Bio Mater. 2021 ;4(4):3614-3622.
[4]Hui Liu,Zhenghu Jia, Chengmao Yang, Mei Song, Zhe Jing, Yapu Zhao, Liqing Zhao, Zhenzhou Wu, Dongsheng Wei, Zhinan Yin, Zhangyong Hong. Aluminum hydroxide colloid vaccine encapsulated in yeast shells with enhanced humoral and cellular immune responses.Biomaterials.2018; 167:32-43.
[5] Hui Liu,Mei Zhao, Jin Wang, Mingpei Pang, Zhenzhou Wu, Liqing Zhao, Zhinan Yin, Zhangyong Hong.Photodynamic therapy of tumors with pyropheophorbide a loaded polyethylene glycol–poly (lactic-co-glycolic acid) nanoparticles [J].International Journal of Nanomedicine,2016;11:4905-4918.
[6] Jin Wang, Qian Liu, Yuting Zhang, Huan Shi,Hui Liu,Wenjun Guo, Yanhong Ma, Weiqiang Huang Zhangyong Hong. Folic acid conjugated pyropheophorbidea as the photosensitizer tested for in vivo targeted photodynamic therapy.Journal of Pharmaceutical Sciences, 2017;106(6), 1482-1489.
[7] Guangchao Cao, Qian Wang, Jiyu Tong, Wanjun Huang, Dewei Ye, Yan He,
Zonghua Liu, Xin Tang, Hao Cheng, Qiong Wen, Dehai Li, Hau Tak Chau, Yiming Wen, Hui Zhong,Ziyu Meng,Hui Liu,Zhenzhou Wu, Liqing Zhao, Richard Flavell, Hongwei Zhou, Aimin Xu, Hengwen Yang, and Zhinan Yin. Long term consumption of caffeine-free high-sucrose cola beverages aggravates the pathogenesis of EAE in mice.Cell Discovery,2017 ;3:17020.
[8] Guangchao Cao, Qian Wang, Guangqiang Li,Ziyu Meng,Hui Liu,Jiyu Tong, Wanjun Huang, Zonghua Liu, Jun Wei, Hongbo Chi, Hengwen Yang, Liqing Zhao, Zhenzhou Wu, Jianlei Hao, Zhinan Yin. mTOR inhibition potentiates cytotoxicity of Vγ4 γδ T cells via up-regulating NKG2D and TNF-α [J].Journal of Leukocyte Biology,2016;100:1181-1189.
[9] Rong Luan, Hao Cheng, Lin Li,HuiLiu, Qiang Zhao,Zhenzhou Wu, Liqing Zhao, Zhinan Yin.Maternal Lipopolysaccharide Exposure Promotes Immunological Functional Changes in Adult Offspring CD4(+) T Cells.[J].American Journal of Reproductive Immunology,2015; 73(6):522.
