郭春磊，南開(kāi)大學(xué)理學(xué)博士，副教授，碩士生導(dǎo)師，2017年至今就職于新鄉(xiāng)醫(yī)學(xué)院醫(yī)學(xué)檢驗(yàn)學(xué)院。目前的研究方向?yàn)槟[瘤免疫，主要從事腫瘤干細(xì)胞與腫瘤微環(huán)境之間相互調(diào)控的機(jī)制研究。累計(jì)主持國(guó)家自然科學(xué)基金1項(xiàng)，河南省高校重點(diǎn)科研項(xiàng)目1項(xiàng)，在Theranostics、Front Bioeng Biotechnol、Int J Pharm等雜志發(fā)表SCI論文7篇。
【研究工作經(jīng)歷】
2017.07-2021.12 新鄉(xiāng)醫(yī)學(xué)院醫(yī)學(xué)檢驗(yàn)學(xué)院 講師
2022.01-至今 新鄉(xiāng)醫(yī)學(xué)院醫(yī)學(xué)檢驗(yàn)學(xué)院 副教授
【承擔(dān)及完成課題】
1. FBF1促進(jìn)乳腺癌細(xì)胞干性和侵襲轉(zhuǎn)移的機(jī)制研究，國(guó)家自然科學(xué)基金青年項(xiàng)目，2019.01--2021.12，主持，21萬(wàn)元。
2. FBF1調(diào)控腫瘤干細(xì)胞特性促進(jìn)乳腺癌血管新生的機(jī)制研究，河南省高等學(xué)校重點(diǎn)科研項(xiàng)目，2019.01--2020.12，主持，5萬(wàn)元。
3.炎癥相關(guān)基因調(diào)控腫瘤細(xì)胞干性和轉(zhuǎn)移的機(jī)制研究，博士啟動(dòng)基金，主持，50萬(wàn)元。
【代表性論著】（#為第一作者，*為通訊作者）
1.Guo Chunlei#, Chen Yanan#, Gao Wenjuan, Chang Antao, Ye Yujie, Shen Wenzhi, Luo Yunping, Yang Shengyong, Sun Peiqing, Xiang Rong*, and Li Na*. Liposomal Nanoparticles Carrying anti-IL6R Antibody to the Tumour Microenvironment Inhibit Metastasis in Two Molecular Subtypes of Breast Cancer Mouse Models. Theranostics. 2017 ;7(3):775-788.
2.Guo Chunlei#, Li Shuang#, Liang Ang, Cui Mengchao, Lou Yunwei and Wang Hui*. PPA1 Promotes Breast Cancer Proliferation and Metastasis Through PI3K/AKT/GSK3β Signaling Pathway. Frontiers in Cell and Developmental Biology. 2021;9:730558.
3.Liu Hui#,Guo Chunlei#,Shang Yuhong, Zeng Lin, Jia Haixue, and Wang Zhongyan*. A Supramolecular Nanoparticle of Pemetrexed Improves the Anti-Tumor Effect by Inhibiting Mitochondrial Energy Metabolism. Front Bioeng Biotechnol. 2021 ;9:804747.
4.Hou Jie,Guo Chunlei, Shi Yuzhi, Liu Ergang, Dong Weibing, Yu Bo, Liu Shiyuan, Gong Junbo*. A novel high drug loading mussel-inspired polydopamine hybrid nanoparticle as a pH-sensitive vehicle for drug delivery. Int J Pharm. 2017 ;533(1):73-83.
5. Zhen Ye,Chunlei Guo, Wenzhi Shen, Shuangtao Zhao, Na Luo, Rongrong Wang, Xiaohe Luo, Haiying Niu, Dehong Luo, Shan Jiang, Xiaoyue Tan*, Rong Xiang*. Clinicopathologic significance of legumain overexpression in cancer: a systematic review and meta-analysis. Sci Rep. 2015 ;5:16599.
6. Liu Bowen, Cao Jinling, Wang Xiangyun,Guo Chunlei, Liu Yunxia and Wang Tianjiao. Deciphering the tRNA-derived small RNAs: origin, development, and future. Cell Death Dis. 2021 ;13(1):24.
7. Liu Hui, Zeng Lin, Yang Yang,Guo Chunleiand Wang Hui*. Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation. Front Immunol. 2022 ;13: 847699.
