王磊，男，1979年出生，博士，碩士研究生導師。

聯(lián)系方式：

H/P: 13462389905

e-mail: lwang0522@163.com

教育經(jīng)歷:

2009.01-2012.12，新加坡南洋理工大學，細胞病毒學，博士

2003.09-2006.07，廈門大學，生物化學與分子生物學，碩士

1999.09-2006.07，聊城大學，生物教育，本科

工作經(jīng)歷:

2013/08-至今，   新鄉(xiāng)醫(yī)學院生命科學技術(shù)學院，講師

專業(yè)研究方向

腫瘤生物學

主要科研工作簡介

1.具體研究領(lǐng)域

黑色素瘤增殖和轉(zhuǎn)移的分子機制

2.課題資助

1）NSFC-河南聯(lián)合基金培育項目：E3泛素連接酶環(huán)指蛋白11(RNF11)通過降解Syk促進黑色素瘤轉(zhuǎn)移的分子機制研究（2017.01-2019.12 主持）

2）河南省高等學校重點科研項目計劃：環(huán)指蛋白11通過轉(zhuǎn)化生長因子-β促進黑色素瘤轉(zhuǎn)移的分子機制（2015.01-2016.12 主持）

3）新鄉(xiāng)醫(yī)學院科研培育基金：環(huán)指蛋白11在黑色素瘤轉(zhuǎn)移過程中的分子機制研 （2013.11-2016.12主持）

4）新鄉(xiāng)醫(yī)學院博士啟動基金：環(huán)指蛋白11促進黑色素瘤轉(zhuǎn)移的分子機制研究 （2014.09起）

3.近期代表性論文（已發(fā)表SCI論文30篇）

1)Bin-Feng Cheng, Yao-Xin Gao, Jun-Jiang Lian,Dan-Dan Guo, Lei Wang,* Mian Wang, Hai-Jie Yang*and Zhi-Wei Feng. Hydroxysafflor yellow A inhibits IL-1β-inducedrelease of IL-6, IL-8, and MMP-1 via suppression ofERK, NF-κB and AP-1 signaling in SW982 humansynovial cells. Food & Function, DOI: 10.1039/c6fo01045h(* corresponding author).

2)Lei Wang,Qiong-Qiong Ding,Shan-Shan Gao,Hai-Jie Yang,Mian Wang,Yu Shi,Bin-Feng Cheng,Jia-Jia Bi,Zhi-Wei Feng.PRDM5 promotes the proliferation and invasion of murine melanoma cells through up-regulating JNK expression. Cancer Medicine,2016; 5(9):2558–2566.

3)Yan Wang, Chen-yan Zhou, Hong Ming, Jing Kang, Hong-li Chen,Chang-qin Jing, Hui-gen Feng, Ya-ke Chang, Zhen-hao Guo,Lei Wang*. Pseudofulvibacter marinus sp. nov., isolatedfrom seawater. International Journal of Systematic and Evolutionary Microbiology, 2016, (66), 1301–1305(*corresponding author).

4)Lei Wang, Hai-Jie Yang, Shan-Shan Gao, Mian Wang, Yu Shi, Bin-Feng Cheng and Zhi-Wei Feng. Identification of a novel role of RING finger protein 11 promoting the metastasis of murine melanoma cells. Am J Transl Res, 2015, 7(9): 1629–1635.

5)Lei Wang,Bin-Feng Cheng, Hai-Jie Yang, Mian Wang, Zhi-Wei Feng.NF-κB protects human neuroblastoma cells from nitric oxide-induced apoptosis through upregulating biglycan. Am J Transl Res,2015, 7(9):1541-1552.

6)Hai-Jie Yang,Lei Wang,Mian Wang,Shuang-Ping Ma, Bin-Feng Cheng,Zhi-Chao Li, Zhi-Wei Feng.Serine/Threonine-protein kinase PFTK1 modulates oligodendrocyte differentiation via PI3K/AKT pathway. J Mol Neurosci, 2015, 55:977-984.

7)Hai-Jie Yang,Lei Wang,Shu-LiChen, Mian Wang,Zhi-Wei Feng.Effect of a double-structured microporous polymer support on the catalytic activity, stability and aggregation behavior of immobilized enzymes. Polymer Int, 2015, 64(7):915-923.

8)Hai-Jie Yang, Pei Feng, Lei Wang, Zhi-Chao Li, Shuang-Ping Ma, Mian Wang, Zhi-Wei Feng. Caveolin-1 mediates genetransfer and cytotoxicity of polyethyleneimine in mammalian cell lines.Mol Cell Biochem, 2015, 402: 203-211.

9)Hai-Jie Yang, Mian Wang , Lei Wang, Bin-Feng Cheng, Xiao-Yu Lin, Zhi-Wei Feng, NF-κB regulates caspase-4expression and sensitizes neuroblastoma cells to Fas-induced apoptosis.PLoSOne, 2015, 10(2): e0117953-e0117953.

10)Lei Wang, Yu Shi, Peijun Ju, Rui Liu, Siok Ping Yeo, Yinyan Xia, Zhiwei Feng. Silencing of diphthamide synthesis 3 (Dph3) reduces metastasis of murine melanoma. PLoS ONE, 2012, 7(11):e49988. doi: 10.1371/journal.pone.0049988.

11)Yu Shi, Yin-Yan Xia, Lei Wang,Rui Liu, King-Shung Khoo, Zhi-Wei Feng. Neural Cell Adhesion Molecule modulates Mesenchymal Stromal Cell migration via activation of MAPK/ERK signaling. Experimental cell research,2012,318(17), 2257-67.

12)Bin Zhi, Lei Wang, Guangyi Wang, Xiaobo Zhang. Contribution of the caspase gene sequence diversification to the specifically antiviral defense in invertebrate. PLoS ONE, 2011, 6, e24955.

13)Rui Liu, Yu Shi, Hai Jie Yang, Lei Wang, Si Zhang, Yin Yan Xia, Jing Lin Jack Wong, and Zhi-Wei Feng. Neural Cell Adhesion Molecule Potentiates the Growth of Murine Melanoma via β-Catenin Signaling by Association with Fibroblast Growth Factor Receptor and Glycogen Synthase Kinase-3β. Journal of Biological Chemistry, 2011, 286, 26217-26317.

14)Hai-Jie Yang, Yin-Yan Xia, Lei Wang, Goh-Kim Jee, Yu Shao, Zhi-Wei Feng. A novel role forneural cell adhesion molecule in modulating insulin signaling and adipocyte differentiation of mouse mesenchymal stem cells. Journal of Cell Science, 2011, 124, 2552-2560.

15)Lei Wang, Hai-Jie Yang, Yin-Yan Xia, Zhi-Wei Feng. Insulin-like growth factor 1 protects human neuroblastoma cells SH-EP1 against MPP+-induced apoptosis by AKT/GSK-3β/JNK signaling. Apoptosis, 2010, 15 (12), 1470-1479.

16)Hai-Jie Yang, Lei Wang, Yin-Yan Xia, Piek-Ngoh Chang, Zhi-Wei Feng. NF-kappaB mediates MPP+-induced apoptotic cell death in neuroblastoma cells SH-EP1 through JNK and c-Jun/AP-1. Neurochemistry International, 2010, 56:128-134.

17)Lei Wang, Bin Zhia, Wenlin Wua, Xiaobo Zhang. Requirement for shrimp caspase in apoptosis against virus infection. Developmental and Comparative Immunology, 2008, 32, 706–715.

18)Wenlin Wu, Lei Wang, Xiaobo Zhang. Identification of white spot syndrome virus (WSSV) envelope proteins involved in shrimp infection. Virology, 2005, 332, 578–583 (Co-first authorship)