個人簡介
徐永濤，中共黨員，博士研究生，副教授，碩士研究生導(dǎo)師，河南省高?？萍紕?chuàng)新人才，新鄉(xiāng)醫(yī)學(xué)院“太行青年學(xué)者”，新鄉(xiāng)醫(yī)學(xué)院“青年教學(xué)標(biāo)兵”，新鄉(xiāng)醫(yī)學(xué)院醫(yī)學(xué)工程學(xué)院醫(yī)學(xué)裝備成果轉(zhuǎn)化辦公室主任，新鄉(xiāng)市生物醫(yī)學(xué)信息研究重點實驗室主任，河南省神經(jīng)信息分析與藥物智能設(shè)計國際聯(lián)合實驗室常務(wù)副主任，中國醫(yī)藥教育協(xié)會智能醫(yī)學(xué)專業(yè)委員會常務(wù)委員。2013年12月獲得英國女王大學(xué)計算生物學(xué)與計算化學(xué)博士學(xué)位。主要從事醫(yī)學(xué)信息研究方面的教學(xué)科研工作，研究方向為計算機輔助藥物設(shè)計，人工智能在醫(yī)學(xué)方面的應(yīng)用。近年來個人共發(fā)表論文32篇，其中SCI論文26篇，中文核心6篇，參與學(xué)術(shù)著作2部。主持或參與國家自然科學(xué)基金青年科學(xué)基金項目4項，國家留學(xué)基金委項目1項。主持并完成省級項目3項。第二屆全國智能技術(shù)應(yīng)用大賽一等獎、中國醫(yī)藥教育協(xié)會科技創(chuàng)新獎二等獎。
聯(lián)系方式：
新鄉(xiāng)醫(yī)學(xué)院北校區(qū)科技樓七樓733室
電話：0373-3831393
mail: yxu@xxmu.edu.cn;
研究方向：
計算機輔助藥物設(shè)計：抗癌和抗病毒小分子創(chuàng)新藥物研發(fā)
人工智能在醫(yī)學(xué)上的應(yīng)用：臨床與生物醫(yī)學(xué)大數(shù)據(jù)融合技術(shù)；臨床輔助診療
招生方向：
學(xué)術(shù)學(xué)位碩士（學(xué)碩）：生物醫(yī)學(xué)工程
專業(yè)學(xué)位碩士（專碩）：生物與醫(yī)藥、電子信息
教育經(jīng)歷：
2010/09-2013/12，英國女王大學(xué)，計算生物學(xué)與計算化學(xué)，博士
2009/09-2010/08，浙江大學(xué)，軟件工程，碩士
2001/09-2006/07，北京科技大學(xué)，信息管理與信息系統(tǒng)，學(xué)士
承擔(dān)項目：
1. 國家自然科學(xué)基金委員會，青年項目，21603180，計算設(shè)計以信封蛋白為靶點的抗登革熱病毒肽抑制劑與初步實驗驗證，2017-01至2019-12，20萬元，結(jié)項，主持
2. 國家自然科學(xué)基金委員會, 面上項目, 82273816，LSD1/MAO特異性激活的喜樹堿類LSD1/TopoI雙重抑制劑的設(shè)計合成、抗腫瘤活性評價及協(xié)同免疫治療研究，2023-01至2026-12，52萬元，在研，第一參與人
3. 國家自然科學(xué)基金委員會, 聯(lián)合項目, U1704184，特異性靶向LSD1小分子降解劑的設(shè)計、合成及抗腫瘤活性研究，2018-01至2020-12，51萬元，結(jié)項，第一參與人
4. 國家自然科學(xué)基金委員會，青年項目，21803049，黃酮醇-金納米抗氧化劑生物界面性質(zhì)和生物相容性的研究，2019-01至2021-12，26萬元，結(jié)項，第二參與人
5. 國家留學(xué)基金委，地方合作項目，201708410492，計算設(shè)計螺旋蛋白為靶點的抗癌抑制劑研究，2018-09至2019-09,15萬元，結(jié)項，主持
6. 河南省教育廳，河南省高?？萍紕?chuàng)新人才項目，22HASTIT050, 計算設(shè)計精準(zhǔn)靶向主蛋白酶的抗新冠病毒小分子抑制劑及實驗驗證，2022-01至2024-12，30萬元，在研，主持
7.河南省教育廳，河南省科技攻關(guān)項目，202102310875, 計算設(shè)計抗新冠病毒小分子藥物及實驗驗證，2021-01至2022-12，在研，主持
6. 河南省人力資源和社會保障廳，2023年度留學(xué)人員科研擇優(yōu)資助項目，新型苯并呋喃核HCV NS5B聚合酶泛基因型抑制劑的計算設(shè)計與分子模擬研究，2023-01至2024-12，5萬元，在研，主持
8. 河南省財政廳，河南省外專局項目，2014【131】，統(tǒng)計勢能在評價蛋白穩(wěn)定性的應(yīng)用，2014-10至2015-01,5萬元，結(jié)項，主持
近五年代表性論文
(1) Gao Q, Guo Y, Cao P, Fan G, Xu Y*. Regioselective synthesis of indazolo[2,3-a]quinazolines enabled by I2/S-facilitated annulation relay dehydrogenative aromatization of cyclohexanones. Chem Commun (Camb). 2023 Nov 21;59(93):13835-13838.SCI/二區(qū)top/6.1
(2) 賈夢珠,韓迪,路嘉瑞,高云龍,徐永濤*.基于丁酸鈉的新型HDAC4抑制劑的設(shè)計與模擬[J].化學(xué)研究與應(yīng)用,2023,35(07):1556-1564.中文核心期刊
(3) 暢豫霄,董亞東,徐永濤*.基于圖卷積神經(jīng)網(wǎng)絡(luò)和拓?fù)涮卣鞯奈⒑颂呛怂?/span>-疾病關(guān)聯(lián)預(yù)測模型[J].生物醫(yī)學(xué)工程研究,2023,42(02):122-130.中文核心期刊
(4) Duan Y, Yu T, Jin L, Zhang S, Shi X, Zhang Y, Zhou N, Xu Y*, Lu W, Zhou H, Zhu H, Bai S, Hu K, Guan Y. Discovery of novel, potent, and orally bioavailable HDACs inhibitors with LSD1 inhibitory activity for the treatment of solid tumors.[J] .Eur J Med Chem, 2023, 254: 115367.SCI/一區(qū)/5.6
(5) Li T, Cui N, Fan J, Liu X , Guan J, Zhang W, Li Y, Gao Q, Liu Y, Xu Y, Wan L, Guo C, and Wang Y. Engineering β agarase Aga0917 from Pseudoalteromonas fuliginea YTW1-15 1 to Improve the Thermostability and Enzyme Activity: ACS Sustainable Chem. Eng. 2022, 10, 15437?15449.SCI/一區(qū)/8.1
(6) Xu Y, Fan B, Gao Y, Chen Y, Han D, Lu J, Liu T, Gao Q, John Zhang Z, Wang M. Design Two Novel Tetrahydroquinoline Derivatives against Anticancer Target LSD1 with 3D-QSAR Model and Molecular Simulation.Molecules. 2022 Nov 30;27(23):8358.SCI/二區(qū)/4.9
(7) Zhou X, Zhao F, Xu Y, Guan Y, Yu T, Zhang Y, Duan Y?，Zhao Y?. A comprehensive review of BET-targeting PROTACs for cancer therapy, Bioorganic & Medicinal Chemistry, 2022(73).SCI/三區(qū)/3.6
(8) Gao Q, Sun Z, Wu M, Guo Y, Han X, Yan J, Ha M,Le Q, Xu Y?. Di-tert-butyl peroxide as an effective two-carbon unit in oxidative radical cyclization toward 7-methylazolo[1,5-a] pyrimidines, Org Chem Front,2022(04).SCI/一區(qū)/5.3
(9) Xu Y?, Gao Y, Yang M, Wang M, Lu J, Wu Z, Zhao J, Yu Y, Wang C, Zhao Z, Gao Q, Duan Y?, Han D?. Design and identification of two novel resveratrol derivatives as potential LSD1 inhibitors. Future Med Chem, 2021, 13: 1415-1433.SCI/二區(qū)/3.8
(10) 陳依帆,趙俊強,楊敏,賀子豪,高云龍,劉鴻儀,徐永濤*.二苯乙烯類LSD1抑制劑的分子對接及分子動力學(xué)模擬研究[J].分子科學(xué)學(xué)報,2021,37(03):206-213.中文核心/中國科技核心期刊
(11) Zhao Z,Li J,Niu Y,Wang C, Zhao J, Yuan Q, Ren Q, Xu Y, Yu Y. Classification of Schizophrenia by Combination of Brain Effective and Functional Connectivity. Front Neurosci, 2021(15): 651439. SCI/二區(qū)/3.7
(12) Duan Y*, Jin L, Ren H, Zhang S, Liu Y, Xu Y, He Z, Song Y, Yuan H, Chen S, Guan Y*. Design, synthesis, and biological evaluation of novel dual inhibitors targeting lysine specific demethylase 1 (LSD1) and histone deacetylases (HDAC) for treatment of gastric cancer. European Journal of Medicinal Chemistry.2021 ( 220) 113453. SCI/一區(qū)/6.5
(13) Li X, Liu H, Wu X, Xu R, Ma X, Zhang C, Song Z, Peng Y, Ni T*, Xu Y?. Exploring the interactions of naringenin and naringin with trypsin and pepsin: Experimental and computational modeling approaches. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2021(258 ) 119859. SCI/二區(qū)/4.1
(14) Yu J, Li X, Liu H, Peng Y, Wang X, Xu Y. Interaction behavior between five flavonoids and pepsin: Spectroscopic analysis and molecular docking. Journal of Molecular Structure,2020(1223),128978. SCI/三區(qū)/3.1
(15) 劉鴻儀,楊敏,陳依帆,賀子豪，張松杰，徐永濤*.Mtb_G5K同源建模及其與[3, 2-c]喹啉對接研究.化學(xué)研究與應(yīng)用,2020, 32(7):1200-1206.中文核心/CA收錄
(16) Gao Q, Wu M, Zhang K, Yang N, Liu M, Li J, Fang L, Bai S, Xu Y?. I-2-Catalyzed Aerobic α,β-Dehydrogenation and Deamination of Tertiary Alkylamines: Highly Selective Synthesis of Polysubstituted Pyrimidines via Hidden Acyclic Enamines. Org Lett, 2020,22(14), 5645-5649. SCI/一區(qū)/6.5
(17) Zhao Z, Wang C, Yuan Q, Zhao J, Ren Q, Xu Y, Li J, Yu Y?. Dynamic changes of brain networks during feedback-related processing of reinforcement learning in schizophrenia. Brain Research, 2020(1746), 146979.SCI/三區(qū)/3.2
(18) Wang C, Zhao Z, Ren Q, Xu Y, Yu Y?.A novel multi-focus image fusion by combining simplified very deep convolutional networks and patch-based sequential reconstruction strategy. Applied Soft Computing Journal，2020, 91, 106253. SCI/二區(qū)/6.7
(19) Li X?, Peng Y, Liu H, Xu Y, Wang X, Zhang C, Ma X. Comparative studies on the interaction of nine flavonoids with trypsin. Spectrochim Acta A Mol Biomol Spectrosc, 2020, 238, 118440. SCI/二區(qū)/4.1
(20) Xu Y*, He Z, Liu H, Chen Y, Gao Y, Zhang S, Wang M, Lu X, Wang C, Zhao Z, Liu Y, Zhao J, Yu Y, Yang M*. 3D-QSAR, molecular docking, and molecular dynamics simulation study of thieno[3,2-b]pyrrole-5-carboxamide derivatives as LSD1 inhibitors. RSC Adv, 2020, 10, 6927–6943. SCI/三區(qū)/3.3
(21) Xu Y*, He Z, Yang M, Gao Y, Jin L, Wang M, Zheng Y, Lu X, Zhang S,Wang C, Zhao Z,Zhao J, Gao Q*, Duan Y*. Investigating the Binding Mode of Reversible LSD1Inhibitors Derived from Stilbene Derivatives by 3D-QSAR, Molecular Docking, and Molecular Dynamics Simulation. Molecules, 2019, 24(24): 4479. SCI/三區(qū)/4.4
(22) 賀子豪,趙俊強,楊敏,張松杰,徐永濤*.使用遺傳算法優(yōu)化登革熱病毒信封蛋白的肽抑制劑. 河南師范大學(xué)學(xué)報(自然科學(xué)版), 2019, 47(06):38-44. 中文核心
(23) Wang C , Zhao Z , Ren Q , Xu Y, Yu Y*. Dense U-net Based on Patch-Based Learning for Retinal Vessel Segmentation. Entropy, 2019, 21, 168. SCI/三區(qū)/2.5
(24) Lu X*, Zhang T, Wan R, Xu Y, Zhao C, Guo S. Numerical investigation of narrowband infrared absorber and sensor based on dielectric-metal metasurface, Optics Express, 2018, 26(8):10179. SCI/二區(qū)/3.9
(25) 趙俊強*，徐永濤，陳繼超. 基于 Shearlet 變換結(jié)合動態(tài)融合的遙感圖像融合算法.電子測量與儀器學(xué)報. 2018,32(11):35-42. CSCD
(26) Amir-Hassan A, Lee VS, Baharuddin A, Othman S, Xu Y, Huang M, Yusof R, Rahman NA, Othman R*. Conformational and energy evaluations of novel peptides binding to dengue virus envelope protein. Journal of Molecular Graphics & Modelling, 2017, 74:273-287. SCI/四區(qū)/2.5
(27) Yu L, Xu Y*, Wang F, Yang C, Liu G, Song X. Functional Roles of Pattern Recognition Receptors That Recognize Virus Nucleic Acids in Human Adipose-Derived Mesenchymal Stem Cells. Biomed Research International, 2016, 9872138. SCI/三區(qū)/3.4
(28) Mooney M ，Xu Y，Mcclory J，Huang M*. A disappearing act performed by magnesium: the nucleotide exchange mechanism of Ran GTPase by quantum mechanics/molecular mechanics studies. Theoretical Chemistry Accounts, 2016, 135(8). SCI/三區(qū)/1.8
(29) Xu Y, Yu S, Zou J , Huang M*. Identification of peptide inhibitors of enveloped viruses using support vector machine. PLoS One，2015 Dec 4;10(11):e0144171. SCI/三區(qū)/3.2
(30) Xu Y, Zho Xu, Huang M*. StaRProtein, A Web Server for Prediction of the Stability of Repeat Proteins. Plos One. 2015 Mar 25;10(3):e0119417. SCI/三區(qū)/3.2
(31) Aida B, Amir HA, Othman R, Xu Y, Huang M, Ario TB, Yusof R, Abdul RN, Othman S*. Dengue envelope domain III-peptide binding analysis via tryptophan fluorescence quenching assay. Chemical&pharmaceutical Bulletin, 2014，62(10), 947-955. SCI/四區(qū)/1.4
(32) Xu Y, Rahman N, Othman R, Hu P, Huang M*. Computational identification of self-inhibitory peptides from envelope proteins. Proteins, 2012, 80(9), 2154-68. SCI/三區(qū)/3.7
