沈萍

作者: 時間:2022-09-16 點擊數(shù):

女,19807月生。博士,新鄉(xiāng)醫(yī)學(xué)院特聘教授。長期從事自體性免疫疾病的分子和細(xì)胞機(jī)制及干細(xì)胞的免疫調(diào)節(jié)作用研究,同時從事B細(xì)胞和漿細(xì)胞在自體免疫疾病和感染性疾病中的調(diào)節(jié)作用研究。曾參與德國國家自然科學(xué)基金及德國Hertie獎學(xué)金各一項,現(xiàn)主持新鄉(xiāng)醫(yī)學(xué)院特聘教授研究課題1項,迄今在Nature、PNAS等雜志發(fā)表SCI收錄文章20余篇,累計影響因子超過100分?,F(xiàn)為德國免疫學(xué)學(xué)會會員,2015年獲得歐洲免疫學(xué)會年度優(yōu)秀科技工作者稱號。

聯(lián)系方式:

0373-3029887office E-mail: pingzaizai@hotmail.com

學(xué)習(xí)和工作經(jīng)歷:

2007.9–2014.6,德國柏林洪堡大學(xué),細(xì)胞免疫,博士

2003.9–2006.6,中國科學(xué)院上海生命科學(xué)研究院,細(xì)胞生物學(xué),碩士

1999.9–2003.6,河南師范大學(xué),生物學(xué),學(xué)士

主要研究方向:

自體性免疫疾病的細(xì)胞和分子機(jī)制的研究

教學(xué)成果:

從事研究生干細(xì)胞及免疫調(diào)控等課程教學(xué)工作,參與編寫專著2部。

主要科研工作簡介

2016.1-至今,新鄉(xiāng)醫(yī)學(xué)院,生命科學(xué)技術(shù)學(xué)院,特聘教授

2014.7-2015.12,德國風(fēng)濕病研究中心(DRFZ),柏林Leibniz研究所,博士后

2014.6-2015.12,德國柏林洪堡大學(xué),博士后,合作導(dǎo)師:Simon Fillatreau

課題資助:

1.      國家自然科學(xué)基金面上項目經(jīng)血源性子宮內(nèi)膜干細(xì)胞對中樞神經(jīng)系統(tǒng)自身免疫疾病的治療和機(jī)制研究,57萬,2017-2019,主持;

2.      新鄉(xiāng)醫(yī)學(xué)院高層次人才科研啟動項目,50萬,在研,主持;

3.      德國國家自然科學(xué)基金,SFB 650,2013-2015,20萬歐元;

4.      Hertie獎學(xué)金,Hertie Stiftung2011-2013,10萬歐元。

代表性論文:

1.       Ping Shen, Sebastian Servea, Peihua Wua, Xiaohui Liua, Yujie Daia,  Nayar Durán-Hernándeza, Dan Thi Mai Nguyena, Michael Fuchsd, Tazio Maleitzkee, Marie-Jacqueline Reisenere, Maria Dzamukovaa, Katrin Nussbaumera, Tobias M. Brunnera, Yonghai Li, Vivien Holecskaa, Gitta A. Heinzh, Frederik Heinrichh, Pawel Durekh, Georgia Katsoulai, Clemens Gwinnere, Tobias Junge, Eleftheria Zegginij,k, Tobias Winklere, Mir-Farzin Mashreghih, Matthias Pumbergere, Carsten Perkae , and Max L?hning. NOS inhibition reverses TLR2-induced chondrocyte dysfunction and attenuates age-related osteoarthritis. Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2207993120.

2.       Li Y, Gao H, Brunner TM, Hu X, Yan Y, Liu Y, Qiao L, Wu P, Li M, Liu Q, Yang F, Lin J, L?hning M, Shen P. Menstrual blood-derived mesenchymal stromal cells efficiently ameliorate experimental autoimmune encephalomyelitis by inhibiting T cell activation in mice. Stem Cell Res Ther. 2022 Apr 11;13(1):155.

3.       Shen P, Wu P, Maleitzke T, Reisener MJ, Heinz GA, Heinrich F, Durek P, Gwinner C, Winkler T, Pumberger M, Perka C, Mashreghi MF, L?hning M. Optimization of chondrocyte isolation from human articular cartilage to preserve the chondrocyte transcriptome. Front Bioeng Biotechnol. 2022 Nov 21;10:1046127.

4.       Shen P, L?hning M. Insights into osteoarthritis development from single-cell RNA sequencing of subchondral bone. RMD Open. 2022 Dec;8(2):e002617.

5.       Shen P, Fillatreau S. Antibody-independent functions of B cells: a focus on cytokines. Nat Rev Immunol. 2015 Jul;15(7):441-51.

6.       Shen P, Fillatreau S. Suppressive functions of B cells in infectious diseases.Int Immunol. 2015 Oct;27(10):513-9.

7.       Shen P, Roch T, Lampropoulou V, O'Connor RA, Stervbo U, Hilgenberg E, Ries S,Dang VD, Jaimes Y, Daridon C, Li R, Jouneau L, Boudinot P, Wilantri S, Sakwa I,Miyazaki Y, Leech MD, McPherson RC, Wirtz S, Neurath M, Hoehlig K, Meinl E,Grützkau A, Grün JR, Horn K, Kühl AA, D?rner T, Bar-Or A, Kaufmann SH, Anderton SM, Fillatreau S. IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature. 2014 Mar 20;507(7492):366-70.

8.       Shen P, Lampropoulou V, Stervbo U, Hilgenberg E, Ries S, Mecqinion A, Fillatreau S.Intrinsic Toll-like receptor signalling drives regulatory function in B cells. Front Biosci (Elite Ed). 2013 Jan 1;5:78-86. (Review)

9.       Shen P, Niu G, Yao M, Wang H, Fei J. Studying on the 19-bp palindrome repeats in human cytomegalovirus immediate early enhancer/promoter reveals their diversity in function for the promoter activity.J Biochem. 2007 142(1):25-31.

Book Chapters:

1.       Ping Shen, Ellen Hilgenberg, Andreia C. Lino, Van Duc Dang, Stefanie Ries, Imme Sakwa, Simon Fillatreau B cells as regulators. Molecular Biology of B cells, Second Edition.(2014)

2.       Hilgenberg E, Shen P, Dang VD, Ries S, Sakwa I, Fillatreau S.Interleukin-10-producing B cells and the regulation of immunity.Interleukin-10 in Health and Disease. (2014)

新鄉(xiāng)醫(yī)學(xué)院生命科學(xué)技術(shù)學(xué)院 版權(quán)所有

新鄉(xiāng)醫(yī)學(xué)院地址:河南省新鄉(xiāng)市紅旗區(qū)金穗大道601號 

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