留學(xué)德國獲得神經(jīng)生物學(xué)博士學(xué)位并在美國NIH從事博士后研究。課題組已承擔(dān)10多項國科基金并在PNAS和Science Signaling等知名期刊發(fā)表科研論文30余篇。兼職中國病理生理學(xué)會和中國科協(xié)科創(chuàng)。

研究方向：蛋白質(zhì)棕櫚酰化修飾的分子和生理功能

蛋白棕櫚?；揎検堑鞍踪|(zhì)翻譯后修飾的一種，在生命活動過程中發(fā)揮著重要的功能。研究表明，S-棕櫚?；揎検莿討B(tài)可逆的脂質(zhì)修飾，廣泛參與了細(xì)胞內(nèi)多樣的調(diào)節(jié)作用。實驗室的研究重點(diǎn)是在生命科學(xué)的多個領(lǐng)域研究蛋白質(zhì)棕櫚?；揎椀姆肿雍蜕砉δ?，使用ZDHHCs和PPTs的基因敲除小鼠模型來探究這些修飾酶的作用。此外，我們還利用遺傳性疾病小鼠模型來了解神經(jīng)退行性疾病、腫瘤發(fā)生和男性不育等病癥的病理機(jī)制，最終的目標(biāo)是揭示這些機(jī)制，并發(fā)現(xiàn)潛在的治療策略，以干預(yù)并阻止疾病的進(jìn)展。

代表成果：

1.Liu, H., Yan, P., Wu, C., Rao, M., Zhu, J., Lv, L., Li, W., Liang, Y., Qi, S., Lu, K., and Kong, E. # (2023) Palmitoylated Sept8-204 modulates learning and anxiety by regulating filopodia arborization and actin dynamics. Science Signaling 16, eadi8645.

2.Tang, D., Zheng, K., Zhu, J., Jin, X., Bao, H., Jiang, L., Li, H., Wang, Y., Lu, Y., Liu, J., Liu, H., Tang, C., Feng, S., Dong, X., Xu, L., Yin, Y., Dang, S., Wei, X., Ren, H., Dong, B., Dai, L., Cheng, W., Wan, M., Li, Z., Chen, J., Li, H., Kong, E.#, Wang, K. #, Lu, K. #, and Qi, S. # (2023) ALS-linked C9orf72-SMCR8 complex is a negative regulator of primary ciliogenesis. Proceedings of the National Academy of Sciences of the United States of America 120, e2220496120.

3.Zhou B, Wang Y, Zhang L, Shi X, Kong H, Zhang M, Liu Y, Shao X, Liu Z, Song H, Li W, Gao X, Chang Y, Dou C, Guo W, Zhang S, Kang X, Gao J, Liang Y, Zheng J, Kong E. #  (2022). The palmitoylation of AEG-1 dynamically modulates the progression of hepatocellular carcinoma. Theranostics. 12(16):6898-6914.

4.Yan, P., H. Liu, T. Zhou, P. Sun, Y. Wang, X. Wang, L. Zhang, T. Wang, J. Dong, J. Zhu, L. Lv, W. Li, S. Qi, Y. Liang and E. Kong# (2022). "Crosstalk of Synapsin1 palmitoylation and phosphorylation controls the dynamicity of synaptic vesicles in neurons." Cell Death & Disease 13(9): 786.

5.Yuan, W., L. Lu, M. Rao, Y. Huang, C. E. Liu, S. Liu, Y. Zhao, H. Liu, J. Zhu, T. Chao, C. Wu, J. Ren, L. Lv, W. Li, S. Qi, Y. Liang, S. Yue, J. Gao, Z. Zhang and E. Kong# (2021). "GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice." Proceedings of the National Academy of Sciences of the United States of America 118(13).

 招生方向:生物化學(xué)與分子生物學(xué);生物技術(shù)與工程

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